Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are blood products that concentrate platelets and growth factors

Purpose of the procedure

he aim of this procedure is to regenerate and promote bladder tissue growth using growth factors present in platelet-rich plasma or platelet-rich fibrin. The procedure may lead to improved bladder function and treatment of certain conditions

What the procedure entails?

Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are blood products that concentrate platelets and growth factors. Platelets play a crucial role in the healing and regeneration of tissue. After administering PRP or PRF to the urinary bladder, a series of biological events occur that contribute to the regeneration and growth of bladder tissue

Indications for the procedure

  • Interstitial cystitis
  • Radiation-induced cystitis
  • Chronic cystitis
  • Chronic pelvic pain
  • Healing problems after bladder surgery


  • Pregnancy and breastfeeding
  • Untreated urinary tract infections
  • Uncontrolled coagulation disorders

Preparation for the procedure

  • Consultation with a doctor
  • Performing a urine culture
  • Discontinuation of antiplatelet and anticoagulant medications
  • In case of urinary tract infection, antibiotic treatment should be administered

Procedure process

The procedure begins with drawing blood from the patient, which is then processed to obtain platelet-rich plasma (PRP) or platelet-rich fibrin (PRF). Next, the patient is given local or general anesthesia. The doctor inserts a cystoscope (a thin, flexible instrument with a camera) into the urethra to obtain an image of the bladder interior. Then, using a thin needle, the platelet-rich plasma or platelet-rich fibrin is injected directly into the bladder

Complications after the procedure

  • Urinary tract infection
  • Bleeding
  • Pain during urination

Post-procedure recommendations

  • Avoiding physical exertion for several days
  • Taking medications according to the doctor's recommendation
  • Informing the doctor of any concerning symptoms
  • Regular follow-up visits with the doctor

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